High Energy Technologies, a company based in California, offers products to actively detect the chemical composition of substances inside a shielded container . What's interesting is its ability to detect the composition of substances at a distances measured in feet. It is based on their core technology, SuperSenzor, developed in conjunction with US government laboratories. Also see this compairson of their products and press release regarding their appearance at a NATO symposium.
In this "active" scanning technique, high-energy neutrons are shone upon the target, which could contain anything from explosives, drugs, or even anthrax. This induces gamma radiation characteristic of the substance inside the shielded container, which is then used to decipher the chemical composition (stoichiometry). By comparison, other non-invasive techniques such as X-rays only indicate the density of the substance.
Contrast this to passive techniques which, by definition, do not require any sort of active probing such as neutrons. These are not yet commercially available. Steps toward remote bomb detection, analogous to how a trained K-9 dog sniffs them out, have been reported in the research literature. For instance, see the following paper explaining a concept based on MEMS technology in which a tiny vibrating hammer-like traps explosive vapor particles emanating from a nearby bomb and crushes them to induce a mini-explosion which can be detected.
Pinnaduwage, L. A., et. al. 2003. “Explosives: A microsensor for trinitrotoluene vapour,” Nature. 425: 474, October 2, 2003.
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